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Myoclonus

 

Myoclonus is involuntary muscle twitching which may be a sign or symptom of many conditions, including certain neurological disorders. Myoclonic twitches may also occur as hypnic jerks, while an individual is falling asleep. They may be classified as positive myoclonus (muscle contractions) or negative myoclonus (muscle relaxations).

Causes:

  • Alzheimer's disease
  • Brain hypoxia
  • Brain tumor
  • Central nervous system disease (CNS disease)
  • Chemical poisoning
  • Creutzfeldt-Jakob disease (CJD)
  • Drug poisoning
  • Epilepsy
  • Kidney failure
  • Lennox-Gastaut syndrome (LGS, rare cause)
  • Lipid storage disorder (lipidoses)
  • Liver failure
  • Multiple sclerosis
  • Nervous system disorder
  • Parkinson's disease
  • Spinal cord injury
  • Stroke
  • Subacute sclerosing panencephalitis (SSPE) / Dawson disease


Types:

Some more common types of myoclonus are labeled as the following:

  • Action myoclonus
  • Cortical reflex myoclonus
  • Essential myoclonus
  • Juvenile myoclonic epilepsy
  • Nocturnal myoclonus / Periodic limb movement disorder (PLMD)
  • Palatal myoclonus
  • Progressive myoclonus epilepsy (PME) / Lafora disease
  • Reticular reflex myoclonus
  • Sleep myoclonus
  • Spinal myoclonus
  • Stimulus-sensitive myoclonus


Diagnosis

Diagnosis of myoclonus is made by a doctor or medical professional. When the diagnosis is being considered by the doctor, other movement disorders should be ruled out, although it is possible for the patient to be suffering from multiple movement disorders. An extensive physical exam may be administered. Additionally, measurements may be taken concerning circulating electrolytes and blood glucose levels. Kidney and liver function tests may be undergone, as well as testing for certain antibodies, drugs and toxins.

Treatment

Treatment for myoclonus involves medications aimed at treating the symptoms. Some of these medications are also used to treat epilepsy. In certain cases, multiple medications may be used together to provide a greater measure of treatment. For short-term use only, alcohol may be taken prior to sleeping to help relieve the symptoms.

See also:

  • Chorea
  • Dystonia
  • Epilepsy
  • Hiccups
  • Hyperrexplexia
  • Hypnic jerk
  • Seizure
  • Tics
  • Tonic-clonic seizure
  • Tremor


Synonyms and other key terms:

  • Muscle contraction
  • Muscle twitch
  • Myoclonic jerks

 

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